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MTHF*R Superpower

The C.L.A.M. (Chloe Lynn Angell-Murray) Foundation for Wellness, LLC

What is MTH*FR Genetic Mutation or Superpower?

MTHFR CONFIDENTIAL HOME TESTING EMPOWEREDX LAB
Or use your DNA Sequencing through Ancestry DNA
Bad Gene Mutation vs. Potential Superpower of MTHFR SNPs You may wonder why MTHFR variants with such negative effects are so common in all population groups. It seems like a variant that should have been weeded out with natural selection. One thing I’ve noticed is that for common negative variants, there is almost always a positive effect that balances it out. Let’s explore the potential positive benefits of MTHFR SNPs. The big positive for MTHFR C677T is that it protects against several common types of cancer. Folate is needed for cell growth, especially fast-dividing cancer cells, and the decrease in folate with MTHFR variants can protect against growth in fast-growing tumors. Studies finding protective effects against cancer:
The MTHFR A1298C variant (GG or GT) is associated with a decreased risk of hypothyroidism. [ref]
The flip side: Folate can also help protect against cancerous mutations in the first place. A lack of folate is linked to double-strand mutations in DNA replications. If those mutations occur in a gene important to cancer prevention, then a tumor can occur.[ref] Thus, folate helps to prevent the mutations that cause cancer, but yet in someone who has cancer, folate and methyl groups can fuel cancer cell growth.
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Gene expression and MTHFR:

MicroRNAs are short strands of RNA that can bind to a mRNA strand and block it from being translated into its protein. In cell studies, folate deficiency upregulates miR-22 and miR-149. These two miRNAs bind to the MTHFR mRNA and keep it from being turned into the MTHFR enzyme when folate is lacking. Interestingly, the effects of folate deficiency regulate miRNA differently in cancer cells vs. non-cancerous cells. Those same miRNAs also affect tumor suppressor genes.[ref] While a lot more research is needed here, the impact of miRNA on both tumor suppressors and MTHFR may be part of why folate is both beneficial for preventing cancer and then detrimental during some types of cancer.
CLAM Awareness Foundation

The Umbrella of Conditions, Disorders, and Diagnoses Linked to MTHFR

Neurological & Mental Health Challenges

Cardiovascular Problems

Reproductive Issues & Pregnancy Complications

Other Physical Health Issues

Developmental & Pediatric Health Issues

Other Genetic & Physical Disorders

CLAM Awareness Foundation

Homocystinuria

This is a condition where the body cannot properly process homocysteine, an amino acid.
Can lead to high homocysteine levels, which can affect eyes and joints and increase the risk of heart disease or stroke.
The gene mutation makes the body unable to make the enzyme needed to process the amino acid called homocysteine include the inability to process and convert Vitamin B-7 (Folate) effectively contributing to imbalances in zinc, calcium, magnesium, vitamin D, while homocysteine levels rise, primarily affecting the brain.

MTHFR and its Impact

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Explanation/Graphic of DNA with MTHFR Mutation, Heterozygous and Homozygous, MRR and COMT

Epigenetic

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